The Alligation Method is one of the four steps in the PHB Chemistry job description. It is a way to calculate molecular weight directly from some reference material. The job of a PHB Chemist is to carry out experiments that relate to the chemistry, and perform work that is directly related to the chemistry. If we will not do it properly, then how will we understand the subject thoroughly?
The Alligation method was invented by Carl Wilhelm Scheele, who worked on hydrogen bonds. He found out that if a molecule has a positive charge, then it can only be hydrogenated with a molecule having a hydrophobic molecule. A molecule having a hydrophobic molecule cannot be hydrogenated with another molecule. Thus, we can see how the calculations are done for the alligation.
Let us study how do you do alligation method of pharmaceutical calculations? First, we need to know the total volume of a molecule. Total volume is equal to volume times mass times its density. Thus, we have the equation: Volume times mass times density or more commonly known as the mean free-form volume. This can be used to calculate the total volume of a molecule.
Now let us look at the second part. How to calculate its total volume using this knowledge? Again, there are different ways to make the calculation. You can use density versus volume, specific gravity, enthalpy of a molecule, etc. Before you can apply any of these methods, you need to know the total volume of a molecule. You can also find the answers to other questions such as:
Why do I need to know the total volume before applying any of the other methods? When you do alligation, a molecule of drug is completely coated with lipids or fats. Once this coating is removed, the molecule will then undergo encapsulation. When encapsulating, the molecule will experience rapid and quite intense heat. Once this heat is experienced, it will be able to release its free forms or atoms.
The total volume of a drug can thus be determined by taking the area where the drug is encapsulated. This will give an idea of how many molecules were released during this process. If you take into consideration the density of the drug, you will then see that the amount of heat applied during this process was significant. This will give a good idea of the amount of drug molecules released.
Is heat released during the process of alligation safe? This is a controversial question especially since there are different points of view. Some people argue that heat has been used before in preparation of medication, thus there is no reason to believe that this method is unsafe. Others however, believe that even small amounts of heat can affect the chemical composition of the medication in any way. Thus, this poses a huge risk to the user and can pose a serious problem for those who work on the compound.
What can be done to minimize the risks of using this method of calculation? First of all, you should only use this method for total Volume calculations and not for other calculations. Second, you should ensure that alligation is performed in an air conditioned environment. Third, you should only have one person performing the procedure at a time. Lastly, it is important to know how much heat is produced during the process and how much total volume is produced during the alligation procedure.
The total volume is calculated as follows: Volume of compound being alligned = total weight of alluvium cambogia / dry weight of cambogia | specific gravity} The specific gravity is calculated as follows: Specific Gravity of compound being alligned = specific gravity of cambogia / dry weight of cambogia. Since the specific gravity of the cambogia is higher than that of the other drug, more heat is required to bring the equilibrium level. Moreover, the temperature change is significant in this process. Therefore, when doing calculations you must take into account the effect of temperature change.
Are there other possible methods of pharmaceutical calculations? If you feel that this article has answered your question “How is the Alligation Method of Pharmaceutical Calculations Used?” then feel free to share with your colleagues and friends.