The Alligation Method of Pharmaceutical Calculations was introduced by J.W. Bowman to calculate the relations among single charges on a molecule, as related to the external forces acting on the molecule. In 1820 J.W. Bowman first applied the method to give value for alkalinity, saltiness, cation exchange and solubility. The method was used to study the reaction between many drugs and their respective compounds. The reactions are usually complicated, involving multiple variables, and can not easily be solved by a single student with little prior knowledge of the subject.
So how do you do the alligation? The first step is to isolate the alkaline, polar, and non-polar molecules from the rest of the chemical compounds. For this, one can use either the unidirectional phase conduction method or the hydrophobic molecule isolation technique. By using either of these techniques one can isolate the alkaline, polar, and non-polar molecules easily. Once they are isolated, you can solve them using the Alligation Equation.
Now how do you do alligation method of pharmaceutical calculations? Here is another twist on the previous question. The total volume of a molecule is equal to the sum of its parts, or more specifically, its total area enclosed by its hydrogen bonding orbitals. Since the total volume of a molecule is the sum of its parts and their hydrogen-bonding orbitals, we know that the total volume must be conserved, i.e., there must be no loss of elements in our calculation. We call this total volume of the molecule, or TV.
The next step is to solve for the enthalpy, or covalent gas charge, of each molecule. To do this we use the Alligation Formula, which is like a more convenient version of an electrochemical formula. Rather than a single number, we have a set of numbers to solve for TV, where each symbol is occupied by a hydrogen-bonding orbital. This is like a grid where each cell in the grid corresponds to a hydrogen-bonding orbital. The hydrogen bonding orbital’s size, area, and angle are calculated, and a new factor, the enthalpy, is calculated from this mixture of numbers.
Finally, we can calculate the total volume by dividing Tv by the total area enclosed by each hydrogen bonding orbital. The formula used is similar to the previous one but now we have a single number to solve for instead of a series of numbers. In order to solve for the enthalpy, we divide Tv by the total area enclosed by each hydrogen bonding orbital, then multiply this by the number of atoms in the molecule. This gives us the enthalpy of the molecule.
What does this have to do with the alligation method of pharmaceutical calculations? Well, the drug molecules actually travel down the channel from their point of origin through the “receptors” on the outer surface of the cells. Once through these cells, they undergo another sort of diffusion process that involves gathering together in what is called an “ovary”. At the destination, the drug molecules travel down the alligator hole into the nucleus of the cell.
This calculation can be done using the knowledge of the total volume and the enthalpy of each molecule of the drug. However, this is only the first step in the calculation. What do you do next? What is the molecular weight of each molecule? How many times the drug molecule has been suspended in water at the molecular level, and how many times it has been exposed to oxygen in the atmosphere?
You can find answers to these questions and more on the website Pharmaceutical Calculators. Not only does the website provide all the answers to your questions about this popular calculation method, but they also have a number of other helpful tools for pharmaceutical engineers. Other sites with information on this topic are included at the website referenced below. After reviewing the website and its many articles and resources, I believe you will find the alligation method of pharmaceutical calculations important in your area of study.